On 15 April 2008, the company that markets Valproat Ratiopharm Chrono, a generic medicine containing valproate used as anti-epileptic, applied to the German medicines regulatory agency to extend its use to include the ‘acute treatment of manic episode and prevention of recurrence in patients with bipolar disorder’.
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These characteristics may partially reflect maturational changes in how the adolescent brain codes and generates responses to social information (Nelson and Guyer, 2011 ; Steinberg, 2008).
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