Sometimes, spices may be ground into a powder for convenience. This may explain why spices are more commonly used in warmer climates, which have more infectious diseases, and why the use of spices is prominent in meat, which is particularly susceptible to spoiling.
The spice trade developed throughout South Asia and Middle East by at least 2000 BCE with cinnamon and black pepper, and in East Asia with herbs and pepper.
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A plant commonly used as a spice, which was shown to increase glucose uptake into the muscle cells without the help of insulin in one Australian study. And I've even been called in to teach about the disease to the up and coming doctors of tomorrow.
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By 1000 BCE, medical systems based upon herbs could be found in China, Korea, and India.