Her comedy addresses social taboos and controversial topics, such as racism, sexism, and religion, having her comic character endorse them in a sarcastic fashion.For her work on television, she won two Primetime Emmy Awards.
Sulkin co-wrote the script of the 2014 film A Million Ways to Die in the West, along with Mac Farlane and Wild.
In March 2011, Sulkin caused a controversy by posting the following joke on Twitter: "If you wanna feel better about this earthquake in Japan, google 'Pearl Harbor death toll.'" Sulkin made the comment one day after the 2011 Tōhoku earthquake, which killed over 10,000 people in Japan.
In August, 2010, Sulkin and his writing partner Wellesley Wild signed a three-year pact with 20th Century Fox TV.
Sulkin, along with Family Guy writers Julius Sharpe, Danny Smith, John Viener, Patrick Meighan and Seth Mac Farlane were special material writers for the 85th Academy Awards, in which the latter was the host.
She also appeared in other television programs, such as Mr. (1997), School of Rock (2003), Wreck-It Ralph (2012), and A Million Ways to Die in the West (2014). Beth had been George Mc Govern's personal campaign photographer and would found the theater company New Thalian Players, while Donald had training as a social worker and also ran the clothing store Crazy Sophie's Outlet. Her sisters are Rabbi Susan Silverman, screenwriter Jodyne Silverman, and actress Laura Silverman; her brother Jeffrey Michael died when he was three months old.