PAK paralogues are found in most mammalian tissues, where they play vital roles in a wide range of functions.
The role of PAKs in cell proliferation and survival, and their involvement in a number of cancers, is of great interest in the context of drug discovery.
In this review we discuss the latest insights into the surprisingly central role human PAK1 plays for the infection by such different infectious disease agents as viruses, bacteria, and parasitic protists.
It is our intention to open serious discussion on the applicability of PAK inhibitors for the treatment, not only of neoplastic diseases, which is currently the primary objective of drug discovery research targeting these enzymes, but also of a wide range of infectious diseases.
The tick injects sporozoites into the blood stream upon feeding; these ‘zoites directly invade the erythrocyte and undergo asexual replication (binary fission) to produce many merozoites that are released into the circulation following erythrocyte rupture and then reinvade erythrocytes, and the cycle continues.