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Disruption of postmitotic maintenance mechanisms may result in neuropsychiatric and neurodegenerative conditions.
The identity of specific cell types in the nervous system is defined by the expression of neuron type–specific gene batteries.
How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades.
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In our hands Lac Z staining was only observed at low level in the CNS and higher levels in other tissues such as testes and blood vessels (see MGI link).